Serotonin Targeting Using Common Antidepressants Induces Rapid Recovery of Cytopenia
نویسندگان
چکیده
منابع مشابه
Antidepressants targeting the serotonin reuptake transporter act via a competitive mechanism.
Although several antidepressants (including fluoxetine, imipramine, citalopram, venlafaxine, and duloxetine) are known to inhibit the serotonin transporter (SERT), whether or not these molecules compete with 5-hydroxytryptamine (serotonin) (5-HT) for binding to SERT has remained controversial. We have performed radioligand competition binding experiments and found that all data can be fitted vi...
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Selective serotonin reuptake inhibitors (SSRIs) are a class of drug widely used for treatment of mood disorders, including depression and cardiovascular disease. A search for related articles in the PubMed database was attempted. It covered studies, reports, reviews and editorials of the last 5 years. Pro-inflammatory cytokines, such as TNF-α, IL-1 and IL-6, stimulate central serotonin (5-HT) n...
متن کاملRapid cyclers, temperament, and antidepressants.
HE GENERAL IMPRESSION of clinicians today is that the course of recurrences of manic-depressive illness has substantially changed in the last 20 yr. The recunences of many patients have become more frequent. One sees more manias and hypomanias and therefore more bipolar cases than before, more rapid cyclers, and more chronic depressions. It is difficult to verify and quantify all these changes,...
متن کاملAntidepressants in long-term therapy: a review of tricyclic antidepressants and selective serotonin reuptake inhibitors.
OBJECTIVE Although depression has been shown to be a long-term disorder, most research studies have concentrated on its acute treatment. METHOD A literature review of the use of tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs) in long-term treatment of depression was performed and recommendations regarding long-term treatment were summarized. RESULTS Stud...
متن کاملRapid recovery from cytopenia in hairy cell leukemia after treatment with 2-chloro-2'-deoxyadenosine (CdA): relation to opportunistic infections.
Sixteen patients with symptomatic hairy cell leukemia were treated with a single course of 2-chloro-2'-deoxyadenosine (CdA), 0.7 mg/kg total dose. Twelve patients achieved complete remission (CR). One patient with a CD19+/CD5+/CD25- phenotype and one with a pentostatin-treated CD19+/CD25- variant form had minor responses. Two patients with advanced disease and poor performance status died early...
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ژورنال
عنوان ژورنال: Blood
سال: 2019
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2019-122658